منابع مشابه
MIF: metastasis/MDSC-inducing factor?
Myeloid-derived suppressor cells (MDSCs) promote tumor growth and metastasis. We have recently demonstrated that the pro-inflammatory cytokine macrophage migration inhibitory factor (MIF) enhances the immunosuppressive microenvironment by increasing the abundance of monocytic MDSCs within the tumor. Our results suggest that MIF is a potential therapeutic target for the prevention of metastasis ...
متن کاملMacrophage migration inhibitory factor (MIF), a role in COPD
Authors: 5 Gunnar R. Husebø, Per S. Bakke, Rune Grønseth, Jon A. Hardie, Thor Ueland, Pål 6 Aukrust, Tomas M.L. Eagan. 7 8 Dept. of Thoracic Medicine, Haukeland University Hospital, Bergen Norway 9 2 Dept. of Clinical Science, University of Bergen, Norway 10 Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway 11 K.G. Jebsen Inflammatory Research Centre...
متن کاملCurrent developments of macrophage migration inhibitory factor (MIF) inhibitors.
The cytokine macrophage migration inhibitory factor (MIF) is regarded as a major regulator of inflammation and a key mediator that counter-regulates the inhibitory effects of glucocorticoids within the immune system. Therefore, MIF is a therapeutic target for the treatment of inflammatory and autoimmune diseases. In addition, MIF was found to be implicated in cancer pathogenesis. Current therap...
متن کاملMechanism of Action of Migration Inhibitory Factor (mif)
The initial interaction between migration inhibitory factor (MIF) and the guinea pig alveolar and peritoneal macrophage was studied. MIF-containing supernatants were generated from sensitized lymph node lymphocytes obtained from guinea pigs immunized with bovine gamma globulin in complete Freund's adjuvant. MIF-containing supernatants were markedly inhibitory for the migration of the peritoneal...
متن کاملMacrophage migration inhibitory factor (MIF) enzymatic activity and lung cancer.
The cytokine macrophage migration inhibitory factor (MIF) possesses unique tautomerase enzymatic activity, which contributes to the biological functional activity of MIF. In this study, we investigated the effects of blocking the hydrophobic active site of the tautomerase activity of MIF in the pathogenesis of lung cancer. To address this, we initially established a Lewis lung carcinoma (LLC) m...
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ژورنال
عنوان ژورنال: Journal of Neuroinflammation
سال: 2014
ISSN: 1742-2094
DOI: 10.1186/1742-2094-11-11